DBCO-NHS ester ( DBCO NHS ester )

产品货号. M11436 CAS No. 1353016-71-3

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

DBCO-NHS ester
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

An amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine.
产品描述

An amine-reactive NHS ester that provides easy attachment of the reactive moiety to almost any primary or secondary amine group, such as that of protein, peptide, or small molecule amine; A click chemistry tool used to conjugate DBCO-PEG4-MMAF to the introduced non-natural amino acid pAMF using a noncleavable linker.
同义词

DBCO NHS ester
通路

Antibody Drug Conjugates (ADC)
靶点

ADCs Linker/Click Chemistry
受体

ADCs Linker/Click Chemistry
研究领域

——
适应症

——

CAS Number

1353016-71-3
分子量

430.45
分子式

C25H22N2O5
纯度

>98% (HPLC)
溶解度

——
SMILES

O=C(CCC(ON1C(CCC1=O)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4
化学全称

Dibenz[b,f]azocine-5(6H)-butanoic acid,11,12-didehydro-γ-oxo-,2,5-dioxo-1-pyrrolidinyl es

1. Currier NV, et al. Mol Cancer Ther. 2016 Jun;15(6):1291-300.

计算器

产品手册

关联产品

DSP Crosslinker

DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs).
DBCO-NHS ester 2

DBCO-NHS ester 2 is a derivative of DBCO (Dibenzylcyclooctyne) used in Cu-free click chemistry.
DSS Crosslinker

DSS Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).It is a homobifunctional crosslinker that is cell membrane permeable. DSS crosslinker has amine-reactive NHS esters at both ends of an 8-atom (11.4 angstrom) spacer arm that are used to conjugate proteins.